Deca-Durabolin, the anabolic steroid

Many athletes use doping products to maximize their performance. Deca-Durabolin, whose active ingredient is nandrolone decanoate, is one of the best-known anabolic steroids used in sports doping. Developed in the 1960s by the Organon laboratory, this synthetic derivative of testosterone was initially designed to treat medical conditions, but has since been diverted from its intended use and become a favorite among competitors. A symbol of the golden age of bodybuilding, many top athletes and professional bodybuilders have admitted to using it to sculpt their bodies or boost their physical performance.

And it's fair to say that it's highly effective in its category, for both muscle gain and joint pain relief, with good anabolic effects and few androgenic effects. What's more, it offers a long duration of action, unique stability and progressive absorption. A must for "clean" gains without too many side effects. Today, Deca-Durabolin is still available on prescription and still misused for doping purposes, although it is easily detectable.

This article looks at how Deca-Durabolin works, its advantages and disadvantages, particularly in sport. You'll find practical recommendations for treatment, advice, a user testimonial and answers to all your questions, for responsible, informed use of this steroid.

Key information

What is Deca-Durabolin?

Deca-Durabolin was developed and first marketed by Organon in 1962, the same laboratory that produced Sustanon. Its chemical component is Nandrolone Decanoate. Basically, it is used by people with extensive burns, for advanced states of malnutrition and in certain cases of osteoporosis.

Deca-Durabolin is an injectable member of the anabolic-androgenic steroid family, with the active ingredient nandrolone decanoate, a nandrolone ester. It takes the form of a light-yellow oily solution dosed at 50 mg/ml, for deep intramuscular injection into the buttocks, thighs or arms. Unlike testosterone, nandrolone is a modified hormone, naturally produced by the body via aromatase from testo, and present in trace form. Its strong point? Its prolonged bioavailability. Basically, after an injection, the active molecule is released for 2 to 3 weeks, with a peak in the first 2 days. Its formula gives it a unique stability in the bloodstream, ensuring gradual absorption.

Chemically, nandrolone is a variant of testosterone without the methyl group in position 19. This modification tends to amplify its anabolic effects while attenuating its androgenic effects You gain muscle without too many masculinizing effects. With a high anabolic/androgenic ratio, it's a good choice when you're looking for quality gains without too many side effects.

From a medical point of view, Deca-Durabolin is basically used to treat renal anaemia, osteoporosis after the menopause and states of undernutrition, including those resulting from disease (AIDS/cancer). Nandrolone acts by stimulating androgen receptors in muscle and bone, boosting protein synthesis, nitrogen retention and EPO production. Some studies show that 100 mg injected generates an anabolic effect lasting over 3 weeks, with almost complete absorption of the product.

For athletes, it's considered a "mild" product, with a strong anabolic effect without the sharp androgenic spikes of testosterone. Nevertheless, like many other doping agents, it suppresses the body's natural production of testosterone and therefore needs to be supplemented with testosterone - to avoid hypogonadism.

Why do athletes use Deca-Durabolin ?

Deca-Durabolin is very popular with sportsmen and women who use steroids, particularly those involved in bodybuilding and strength sports. It's a "classic" used during mass gain cycles in particular. Its popularity dates back to the 1970s, during the Golden Age of bodybuilding, when it was used by legends such as Schwarzy, Zane and Columbo. With its high anabolic ratio, gains of over 10kg of muscle are possible over a 12-week cycle. And without too many side effects (aggressiveness) as with testo or dianabol.

"Deca" is really good for gaining muscle, "dry" muscle without too much water retention. Technically, you gain quality mass, not swelling. The product is also excellent for joints: it helps lubrication, boosts collagen production and eases the pain associated with heavy training. It's a great asset for strength athletes, powerlifters, strongman, Crossfitters, and anyone who "pushes" at the gym. In terms of strength, too, the product delivers. A cycle of Deca-Testosterone boosts your performance and gives you access to strength records. Last but not least, Deca-Testosterone's unique absorption system makes life easier when it comes to injections: one a week is all you need !

Deca-Durabolin is also of interest to endurance athletes, thanks to its erythropoietic role. It increases red blood cells, boosts oxygenation and VO2 max. Cyclists are fond of it for recovery, and many racers have used it (Tour de France).

Deca-Durabolin is obviously banned by WADA (World Anti-Doping Agency), but its use persists. Easily detectable - up to 18 months for urine tests - its very low cost (€20-50/vial on the black market) and the fact that it is fairly well tolerated make it a must-have in the sportsman's pharmacy.

Advantages and disadvantages of Deca-Durabolin

As we've seen, Deca-Durabolin is a favorite among athletes, offering a spectrum of impressive effects. But its use is accompanied by well-documented risks and potential side effects. Like any active substance, "Deca" has advantages and disadvantages that you need to be aware of if you're considering a course of treatment:

Plus points :

- Muscle mass gain: The main advantage of Deca-Durabolin is its ability to build muscle mass by boosting protein synthesis and nitrogen retention. A study on dialysis patients showed muscle gains of 2 to 3 kg in 6 months with 100 mg/week, and 20% for strength. For strength training, gains of 8 to 12 kg over one cycle were reported in a 2004 study published in "Sports Medicine" ⁽¹⁾. 

- Boosted stamina : What's more, the product stimulates erythropoiesis, increasing red blood cells and endurance, useful for combating anemia or boosting prolonged efforts. Confirmed by a 2016 meta-analysis⁽²⁾ with an increase in hemoglobin of 1 to 2 g/dl.

- Joint support : Deca-Durabolin boosts collagen synthesis, reducing inflammation and pain. Confirmed by a 1996 study on 18 men⁽³⁾ which showed a 50% reduction in arthritic symptoms after 12 weeks at 200 mg/week of Deca. The product also improves bone density in post-menopausal women, with an increase of 3-5% in 6 months⁽⁴⁾.

- Little androgenic effect: The risk of conversion to estrogen is lower than for testosterone. Deca-Durabolin has good anabolic effects and few androgenic effects.

Minuses:

Deca-Durabolin has many benefits, but raises concerns, especially with the high doses often used by athletes and bodybuilders in particular (300 to 600 mg/week). A systematic review of 148 studies⁽⁵⁾ has listed the possible side effects:

- Endocrine effects : Suppression of endogenous testosterone (up to 70% after 8 weeks), leading to hypogonadism, infertility and gynecomastia. In women, virilization, deep voice, excessive hair growth, sometimes with irreversible effects⁽⁶⁾. 

- Cardiovascular risks : Arterial hypertension, altered cholesterol levels (20% increase in LDL), coagulation disorders, increased risk of stroke or infarction.

- Skin problems : Severe acne, androgenic alopecia, skin irritation due to the oil used for injection.

- Psychological disorders : Aggressiveness, insomnia, anxiety in 9% of cases. Roid rage" effect possible.

- Effects on growth : In adolescents, the product may impair bone growth and development. Possible risk of tendonitis, despite positive influence via collagen.

- Kidney and liver disorders : Water retention overloads the kidneys. Moderate hepatotoxicity, with transaminase elevations of 20-30%.

- Gastrointestinal disorders : Nausea, vomiting and abdominal pain.

- Libido: Initially increased libido, followed by impotence ("Deca dick"). A major risk with Nandrolone Decanoate is difficulties with libido and erection following a course of treatment. MDT remains essential.

As you can see, the benefits are undeniable when Deca-Durabolin is used in a controlled manner. But the side effects are far from negligible if abused.

How do I use Deca-Durabolin ?

Would you like to take a course of Deca-Durabolin ? This requires a careful approach and caution to minimize risks. To use Deca properly, a medical consultation is recommended before the treatment. Regular blood tests are required to monitor testosterone, liver and cholesterol levels. You should also follow a structured cycle to minimize risks.

How to use Deca-Durabolin :

Here are a few tips to help you manage your treatment with this product:

• Therapeutic dosage : 50 to 100 mg every 2 to 3 weeks. For bodybuilding/weight training: 200 to 400 mg/week for beginners, and up to 600 mg for advanced users, over a maximum of 8 to 12 weeks.
• Tips from Stack deca-Durabolin is not used on its own, but stacked with testosterone to maintain hormonal balance. In combination with Sustanon, this will result in rapid mass gain. However, it is to be feared that this mass is linked to high hydro-sodium retention. With Dianabol, the combination also enables rapid, strong mass gain. Water retention will be even more pronounced.
• Injections : Deep intramuscular application, changing location regularly to avoid abscesses.
• Analysis : pre-cycle, liver function and PSA for prostate. Afterwards, blood tests every 4 weeks (CBC, lipids, hormones). Discontinue in case of hypertension or gynecomastia.
• Hydration : Drink plenty of fluids (4 litres/day) to counteract retention.
• Power supply : High-calorie diet (3000 to 5000 kcal/day), 2 grams of protein/kg.
• For women : The product is not recommended, or at most a low dose (50 mg/week) under supervision, because of virilization.
• Post-cycle therapy (PCT) : A must! Use Clomid (50 mg/day) or Nolvadex (20 mg/day) for 4 weeks, plus HCG to boost testicles. Wait 2 to 3 weeks after the last injection before doing a PCT, as the half-life is long. As for supplements, opt for omega-3 (for the heart), and vitamin D for the bones.

Example of a Deca-Durabolin cycle:

The following is an example of a Deca cycle for an intermediate bodybuilder. Duration: 12 weeks.

Can I take Deca-Durabolin any way I want ?

No. In France, Deca-Durabolin has been classified as a narcotic drug since 2012. You risk 3 years' imprisonment and a €75,000 fine if you possess, sell or use this drug without a medical prescription. In short, it's illegal and only therapeutic uses are authorized. Of course, you can buy it on the black market - which wants to find it - but you run the risk of ending up with adulterated, contaminated or simply under-dosed products. All of which increases the risks..

If you're a sportsman or competitor, you should know that the use of this anabolic steroid has been banned by WADA (World Anti-Doping Agency) since 1976. What's more, its metabolites, such as norandrosterone, are easily detectable in urine for up to 18 months. If caught, you risk a suspension of several years and a lifetime ban in the event of a repeat offence. Remember the case of cyclist Lance Armstrong, who was found to contain traces of nandrolone and stripped of his titles.

So you see, using Deca for your sport is legally risky, unethical and not recommended for your health. It's up to you to decide whether it's worth the risk.

Testimonial from a user of Deca-Durabolin for bodybuilding

Testimony of Dorian, 27, amateur bodybuilder:

" My name is Dorian, 27, and I've been doing amateur bodybuilding for nearly 10 years. I reached my full natural potential 2 years ago, and stagnated for several months looking for solutions in training or supplements. I was plateauing at 85kg with 15% bodyfat, and my joints were starting to give me trouble on heavy exercises. A doping coach acting on Facebook - with a name like a Star Wars character - suggested a Deca-Testo cycle to get me past this plateau and "play in the garnds' court". I followed his instructions to the letter and started with 300 mg/week of Deca and 400 mg of Testo Enanthate for 10 weeks.

The first 2 weeks, nothing special, just a good congestion during the workouts and less aches and pains the following days. Around week 4, Daamn! - As Tiboinshape would say. I'd gained 4 kilos of mass, my shoulders had seriously improved ("3D shoulders"), and my knees weren't giving me any more trouble, allowing me to push well in the squat without pain. The magic potion was working, and I was delighted. At the end of the cycle, I reached 98 kg with 12% less fat, more visible veins and strength to make my training partners pale in comparison (+20% on average). I think the Deca lubricated my joints because I was able to link heavy weights like never before on short sets.

Of course, it hasn't all been rosy, and there have been ups and downs. My libido failed me as early as week 6 - the "Deca dick" as we call it -, and I had to get Cialis so as not to damage my relationship. I also had a bit of water retention in my ankles, and at the end of the cycle I was very tired. I was exhausted... At the end, my testosterone level was 150 ng/dL. I underwent PCT with Clomid, which restored my weight in 6 weeks, but I lost 3.5 kg.

Now, 6 months after the Deca treatment, I weigh 91.5 kg and I'm drier. Nice leftovers, and Deca gave me a solid base. My regrets? Not doing a blood test (low HDL). Let's face it, these products are not for beginners! Without a good coach, you're gambling with your health. If I do another course of treatment, it'll be more for my joints, not just for my "shape". And more follow-up, to better manage the hormonal crash. Of course, I'm not encouraging anyone to use steroids, but sometimes passion is stronger. "

FAQ about Deca-Durabolin

1) How long does Deca Durabolin take to work ?

Deca Durabolin is a long-acting injectable anabolic steroid. It takes longer to work than oral steroids because it releases slowly. You may have to wait several weeks for the effects to kick in, with a peak around week 8 to 10, which is why the course of treatment generally lasts 10 to 12 weeks, with 200 to 600 mg/week. In short, this dopant requires patience. No immediate effect, but lasting gains.

2) What are the most common side effects of Deca-Durabolin ?

Hormonal suppression, with a drop in testosterone, fatigue and loss of libido, is undoubtedly the most dreaded effect. Added to this are water retention, acne and a possible rise in blood pressure. There is also a risk of gynecomastia. In women, virilization problems. Some studies show endocrine disorders in over 40% of cases, fortunately reversible with MDT. It's in your interest not to ignore your blood tests, so you're not sailing blindly.

3) Is Deca-Durabolin suitable for women who want to build muscle ?

No, the product is not recommended for women, due to the high risk of virilization. Deep voice changes, hirsutism, acne, clitoromegaly and menstrual disruption are common side effects. Rather than starting out with lower doses of Deca, opt for Anavar, a good alternative.

4) How long does a typical Deca-Durabolin cycle last ?

2 to 3 months to overcome hormonal suppression. Add a delay of 2 to 3 weeks before MDT. Longer cycles (4 months) are possible, but increase the risk to the heart.

5) Can I take Deca-Durabolin without testosterone ?

No. Since it affects our testosterone production, a stack with Testo is necessary.

6) What dosage of Deca is best for bodybuilding ?

Keep it simple. For beginners, 200 to 300 mg/week. For higher levels, 400 mg. Do not exceed 600 mg to avoid toxicity.

7) Is Deca-Durabolin detectable in anti-doping tests ?

Yes, and easily! Up to 12 to 18 months due to metabolites (norandrosterone). The science of detection is advancing, and even with a short cycle you can get caught.

8) Is Deca-Durabolin harmful to the liver ?

Yes, but less so than orals. Hepatotoxicity is moderate. High doses raise liver enzymes by 20-30%. It's up to you to monitor AST/ALT.

9) How to manage MDT after a Deca cycle ?

Simple and effective. Start 2 to 3 weeks post-injection with HCG 1000 IU every 2 days for 10 days, then Clomid 50 mg/day + Nolvadex 20 mg/day (for 4 weeks). Enough to boost LH/FSH.

10) What is the alternative to Deca-Durabolin ?

Not much! Some use SARMs and/or supplements such as creatine with ecdysteroids. Deca-Max, D-Bal (CrazyBulk) aren't necessarily bad supplements, but they won't do the job.

Finally

Deca-Durabolin is highly effective, both therapeutically and in sports doping. There's no denying it. It's a favorite of bodybuilders and some athletes, with decades of use. But as with most steroids, there are always risks. Especially if you force the dosage during the cure, without supervision. Remain cautious if the urge to take a Deca cure takes hold of you, taking into account the legal and, above all, medical consequences. And get yourself monitored.

Recent studies on Deca-Durabolin

Meta Analysis 1 - Anabolic-androgenic steroids (AAS), such as Nandrolone Decanoate (ND), are commonly used for their muscle mass and strength-enhancing properties. Historically, ND has been used to treat anemia associated with chronic kidney disease and osteoporosis in post-menopausal women. However, its abusive use leads to significant side effects on all body systems, including cardiovascular, endocrine, skin and psychiatric disorders. The mechanisms involved, such as oxidative stress, inflammation and apoptosis, partly explain this damage. While some side effects, such as skin disorders, regress rapidly after discontinuation, others, such as damage to the hormonal, nervous or immune systems, may persist or even become irreversible. Despite numerous studies, research into the consequences of AAS, particularly in humans, remains limited and often contradictory. Most work has been carried out on animal models, as long-term administration of high doses in humans raises ethical concerns. In addition, polydoping and self-reporting by users complicate the analysis of specific effects

of SAA.

A recent systematic review revealed that endocrine (42% of studies) and cardiovascular (14%) disorders are the most frequently reported adverse effects among ND users. These findings highlight the urgent need for further research to better understand the impact of these substances and limit the risks associated with their use.

Source : https://pmc.ncbi.nlm.nih.gov/articles/PMC7696474/ November 2020.

Study 2 - Pilot study demonstrating the beneficial effects of Nandrolone on joint pain in men with hypogonadism. Of the 18 men who responded to follow-up, 13 (72.2%) reported a significant improvement in joint pain, and 5 (27.8%) reported a reduction in the need for medication

long-term analgesics. In patients responding to treatment, pain scores were reduced by an average of 52%. The median duration of treatment was 62 days, with a median Nandrolone dose of 110 mg. The mean age of participants was 46 years.

No adverse effects have been reported. For a long time, testosterone was the main treatment for male hypogonadism, but recent advances have broadened the options available. Among them, Nandrolone stands out for its beneficial effects on joint pain in hypogonadal men, reducing their dependence on chronic analgesics and cutting pain scores by more than half in responder patients.

Although further studies are needed to confirm these results on a larger scale, they suggest a promising clinical use for this drug. Modern andrology is evolving rapidly, offering innovative and promising solutions to improve patient care.

Source : https://tau.amegroups.org/article/view/32338/html March 2020

Sources :

1 - Beyond testosterone cypionate: evidence behind the use of nandrolone in male health and wellness

2 - Bodybuilders' body composition: Effect of Nandrolone decanoate

3 - Deca-Durabolin (Nandrolone): The Ultimate Guide

4 - A medication used to treat anemia caused by poor kidney function.

5 - Nandrolone Decanoate: Use, Abuse and Side Effects

6 - Nandrolone decanoate (deca-durabolin) in primary Sjögren's syndrome: a double blind pilot study